Top 10 Medical Breakthroughs of 2008
1. First Neurons Created from ALS Patients
President-elect Obama has pledged to lift the seven-year ban on federal funding for embryonic stem-cell research — a boon for the field. But for some scientists, it almost doesn't matter. Researchers at Harvard and Columbia reported a milestone experiment in July, using a new method — one that doesn't require embryos at all — to generate the first motor neurons from stem cells in two elderly women with Lou Gehrig's disease, or ALS. The technique, developed by
2. Inflammation vs. Cholesterol
Half of all heart attacks in the
3. Scarless Surgery
Correction Appended: Dec. 15, 2008
It may sound outlandish, but doctors are increasingly experimenting with "natural orifice" surgery, a new technique in which surgeons enter the body through existing openings such as the mouth, vagina and colon, instead of cutting through the skin. A team at the
The original version of this story misstated that the first natural orifice surgery was performed at the
4. Genomes for the Masses
James Watson, co-discoverer of the structure of DNA, did it. So did Craig Venter, co-mapper of the human genome. Now you, too, can map your entire genome and reveal some of its many secrets — for just $399 and a little spit. Scientists debate whether that information is really worth anything at the moment — in many cases, there isn't enough scientific knowledge to interpret what it really means to have this gene variant or that one — but companies like 23 and Me at least make it possible for you to take a gander at your genetic data. (Although the service was available previously, until this year, it's been prohibitively expensive.) You provide a sample of saliva, from which your DNA is extracted, copied and combed for the presence of 90 known genetic variations that code for different traits or conditions, from lactose intolerance (though you could probably drink a glass of milk and find out for far cheaper) to prostate cancer. Right now, there's no way to know whether you'll get cancer just because you have the gene, but once the science has advanced, the hope is that such genetic mining will predict disease, giving people the option of seeking treatment before they get sick.
5. New Genes for Alzheimer's
There is no cure, no vaccine and no way to diagnose Alzheimer's disease without an autopsy. But there may be hope in the discovery of four new genes that contribute to the most common form of the disease. The genes emerged from a study of over 1,300 families, and although the genes' exact role in Alzheimer's isn't known yet, researchers think they may contribute to the death of nerve cells. As the disease progresses, fatty plaques and fibrous tangles of protein build up in the brain, ensnaring nerve cells and eventually strangling them to death. The newly identified genes may shed light on how to keep those nerves alive, which may be an important target for future therapies. Even more exciting is that one of the genes produces a protein that nerve cells use to communicate, another function that declines when Alzheimer's sets in. Dozens of genes have already been linked to Alzheimer's, but each newly discovered gene represents a new target and new hope for future drug treatment.
6. A Five-in-One Vaccine
Any parent can appreciate how much babies hate shots. So, welcome Pentacel, the first vaccine to immunize against five diseases at once — diphtheria, tetanus, pertussis, polio and haemophilus influenzae type B. The vaccine was studied in more 5,000 infants, who showed only minor side effects, including fever, redness and swelling at the injection site. Pentacel still has to be administered in four separate doses, three times between the ages of 2 and 6 months, then again between 15 and 18 months — but it cuts down by 30% on the 23 injections toddlers under 18 months normally receive. Telescoping immunizations may help to get more kids up to date on their immunizations; so far, 77.4% of kids aged 19 to 35 months have received all of their vaccinations, which is just shy of the government's goal of 80% by 2010.
7. Gene Screens for Breast Cancer
Gene screens are fast becoming a powerful tool, not just for diagnosing cancer but for treating it as well. Joining the growing pool of genetic tests for breast cancer, SPOT-Light mines patients' genes to determine who will respond best to the cancer drug Herceptin, which is effective against tumors that release an abundance of the HER2 protein. The SPOT-Light test can measure how many HER2 genes are present in a sample of breast tumor; the more genes there are, the more likely the tumor will respond to treatment with Herceptin. Breast cancer patients are also increasingly relying o n another gene test, OncotypeDx, which can determine the risk of breast cancer recurrence and which chemotherapy agents will work best against a particular tumor.
8. Blood Test for Down Syndrome
One of the best ways to confirm Down syndrome before birth is by amniocentesis, which uses a needle to remove a sample of the amniotic fluid surrounding a fetus. But needles can be nerve-wracking, especially when they're aimed at a growing baby in the womb, and the procedure carries a 1 in 200 risk of miscarriage. Now, a new genetic test may be able to pick up the disease with a simple blood sample from the mom-to-be. Because small amounts of fetal DNA enter the mother's bloodstream, the test is designed to detect abnormally elevated levels of chromosome 21 (an extra copy of it causes Down) in the mother's blood, which would indicate a baby with the disease. The test is still in the development stages, but could herald a new way to identify certain genetic conditions.
9. Seasick Patch for Cancer Patients
Those motion-sickness patches can really help calm a churning stomach on a boat. So, someone decided to apply the same idea to deliver anti-nausea drugs to cancer patients after chemotherapy. In September, the FDA approved Sancuso, a patch that releases a continuous dose of the drug granisetron, which blocks serotonin receptors and reduces queasiness. The prescription drug is already available to cancer patients in solution, tablet or injection form, but the patch makes delivery easier and more convenient. Once on, the Sancuso patch quells nausea and vomiting for about five days.
10. Stem-Cell Trachea Transplant
In a transplant first, doctors in