A Key Gene Involved in Cancer Development is Discovered
OHSU Cancer Institute researchers have identified a gene that is necessary in eliminating cancer cells. The key protein, ASPP2, works by activating biologic pathways that tell cancer cells to die. This protein is proving that it protects cells from one of the steps on the path to cancer. Researchers made this discovery by genetically engineering mice that have a predisposition to cancer because they are lacking one of the genes encoding ASPP2. "This research helps us understand the basics of why cancer cells grow and what kills them so that one day we can develop better therapies and better cancer care for patients," said Charles Lopez, M.D., Ph.D., assistant professor of medicine (hematology/medical oncology), OHSU School of Medicine, and OHSU Cancer Institute member. "This finding is important because expression of this gene is frequently suppressed in many cancers, such as lymphoma and breast cancers," Lopez said. The research was presented at the annual American Association of Cancer Research meeting in San Diego, Calif.
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