Gallbladder cancer
From Special to



Gallbladder cancer and bile duct cancers are relatively rare in the United States. When they do occur, these cancers of the biliary tract affect a disproportionate number of American Indians, Alaska natives and Hispanics, who may have rates five times that of whites. This may be the result of a genetic propensity to gallstones, one of the leading causes of gallbladder cancer.

Gallbladder cancer seldom produces symptoms in the early stages. In fact, early gallbladder cancer is often only discovered when the gallbladder is removed as a treatment for gallstones. Otherwise, gallbladder cancer is often quite advanced by the time it's diagnosed.

When gallbladder cancer is caught early, removing your gallbladder or part of the bile duct may eliminate all the cancerous cells. In advanced cases, treatment will not cure gallbladder cancer but can help relieve symptoms and improve quality of life.


Signs and symptoms


Gallbladder cancer rarely produces signs and symptoms in the early stages. When symptoms do appear, they often resemble those of other, more common, gallbladder problems such as gallstones or infection. These symptoms include:

Signs and symptoms of bile duct cancer (cholangiocarcinoma)
Jaundice, along with tea- or coffee-colored urine and whitish stools, is the most common initial sign of bile duct cancer. Other signs and symptoms include:




Your gallbladder is a small, pear-shaped organ on the right side of your abdomen, just beneath your liver. Its main function is to store bile, a bitter, yellow-green fluid that's produced in the liver cells. Bile is essential for the proper digestion of fats and is one of the main ways your body eliminates drugs, cholesterol and waste products of metabolism. It flows from your liver through a thin tube called the common hepatic duct and enters your gallbladder through another small tube (cystic duct).

When you eat, your gallbladder releases a highly concentrated form of bile into the common bile duct, a continuation of the hepatic and cystic ducts. The bile flows through this duct to the upper part of your small intestine (duodenum), where it begins to break down the fat in your food.

How gallbladder cancer begins
Healthy cells grow and divide in an orderly way — a process that's controlled by DNA, the genetic material that contains the instructions for every chemical process in your body. When DNA is damaged, changes occur in these instructions. One result is that cells may begin to grow out of control and eventually form a tumor — a mass of malignant cells.

Although the exact cause of gallbladder and bile duct cancers isn't clear, researchers believe that DNA in the cells of your biliary tract may be damaged by toxins that are routinely metabolized by your liver. These toxins are released into bile so that they can be eliminated from your body. But if bile empties more slowly than normal, it increases the amount of time your cells are exposed to cancer-causing substances (carcinogens).

Most gallbladder tumors develop in the cells that line the inner surface of the gallbladder. These tumors are known as adenocarcinomas — a term that describes the way the cancer cells look when viewed under a microscope.

Gallbladder adenocarcinoma is highly invasive and can quickly penetrate deep into the gallbladder wall, moving through layers of tissue from the inner surface to the outside of the gallbladder. Eventually the cancer may spread to nearby lymph nodes, obstruct the bile duct or invade other organs such as the liver. Cancer cells may also travel through the bloodstream to more remote parts of the body.

Bile duct cancer (cholangiocarcinoma)
Cancer can develop in any part of the bile duct that stretches from your liver to your small intestine. Many tumors occur in the hepatic duct just as it leaves the liver (perihilar tumors). Other tumors may develop in the bile duct near your small intestine (distal tumors) or inside the liver itself (intrahepatic tumors).

The majority of bile duct cancers are adenocarcinomas that originate in the mucous glands lining the inside of the ducts. By the time these cancers are diagnosed, they often have spread to other tissues and organs.


Risk factors


Researchers have identified a number of factors that may increase your risk of both gallbladder and bile duct tumors.

Gallbladder cancer
Gallstones — solid deposits of cholesterol or calcium salts that form in your gallbladder — are the single greatest risk factor for gallbladder cancer. The stones may cause your gallbladder to release bile more slowly, which increases the amount of time cells are exposed to toxins. Although most people with gallbladder cancer also have gallstones, the vast majority of people with gallstones never develop gallbladder cancer.

Other risk factors include:

Bile duct cancer
Bile duct cancers are rare. They're slightly more common in men than in women and usually develop in middle age. Other risk factors include:


When to seek medical advice


See your doctor right away if you develop any of the signs and symptoms of biliary tract problems, such as jaundice, nausea and vomiting, abdominal pain, severe itching, dark urine, or clay-colored stools. Although these symptoms often aren't related to cancer, they may indicate other conditions that require medical care.


Screening and diagnosis


Many gallbladder cancers are discovered after a pathologist examines a gallbladder that's been removed for other reasons, and nearly half are diagnosed only after signs and symptoms of gallbladder problems appear.

Diagnosing gallbladder cancer earlier than this is difficult because the gallbladder is hidden behind the liver and so is relatively inaccessible, because signs and symptoms don't develop until late in the disease, and because when symptoms do appear, they can easily be mistaken for those of many other conditions.

To help detect the existence and spread of gallbladder cancer, you're likely to have one or more of the following:

Staging biliary tract cancers
Staging tests help determine the size and location of cancer and whether it has spread. This information helps determine the best treatment options.

Doctors stage biliary tract cancers in several ways. One method is as follows:




Gallbladder and bile duct tumors can cause a number of complications including:




Treatment for biliary tract cancers depends on the type and stage of cancer as well as on your age, overall health, feelings and personal preferences. Especially when cancer is advanced, choosing a treatment plan is a major decision, and it's important to take time to consider your choices.

You may also want to consider seeking a second opinion. This can provide additional information to help you feel more certain about the option you're considering.

The goal of any treatment is to eliminate the cancer completely. When that isn't possible, the focus may be on preventing the tumor from growing or causing more harm. In some cases, an approach called palliative care may be best. Palliative care refers to treatment aimed not at removing or slowing the disease, but at helping relieve symptoms and making you as comfortable as possible.

Gallbladder cancer
Surgical removal (resection) of the gallbladder usually offers the best hope for people with gallbladder cancer. If the tumor is very small and hasn't spread to the deeper layers of gallbladder tissue, your surgeon may perform a simple cholecystectomy, which removes only the gallbladder. Sometimes this may be done laparoscopically, using a camera and miniature instruments inserted through small incisions in your abdomen.

If the cancer is more advanced, your surgeon will likely perform what's known as an extended cholecystectomy — an operation in which some liver tissue and nearby lymph nodes are removed along with your gallbladder. Some doctors believe that this operation is a better treatment even for people with very small, localized tumors.

Once the cancer has spread beyond the walls of your gallbladder, it can no longer be completely removed with an operation. In that case, your treatment team will discuss other options with you. These may include external beam radiation — high-energy X-rays that come from a source outside your body — or palliative measures to help make you more comfortable.

Bile duct cancer
Surgery usually offers the best chance for people with bile duct cancer. But the type of operation you may have will vary, depending on the location of the cancer and how extensive it is.

Tumors that develop where the hepatic duct leaves your liver (perihilar tumors) are usually treated by surgically removing a portion of the bile duct, the gallbladder and surrounding lymph nodes.

Distal tumors are often treated with what's known as a Whipple resection. In this operation, your surgeon removes part of your pancreas, the common bile duct and your gallbladder, as well as a small portion of your intestine where the common bile duct and pancreatic duct enter the intestine together.

When a tumor can't be removed — often because it's too close to major blood vessels — your surgeon may suggest an operation to bypass some of your small intestine. This may help prevent further blockage of your bile duct and digestive tract and may also help relieve symptoms. If a bypass isn't an option, your surgeon may place metal or plastic tubes known as stents into the bile duct to keep it open.

Clinical trials
Because standard treatments are rarely effective for advanced biliary tract cancers, you may want to consider participating in a clinical trial. This is a study that tests new therapies — typically new drugs, different approaches to surgery or radiation treatments, and novel methods such as gene therapy. If the therapy being tested proves to be safer or more effective than current treatments, it will become the new standard of care.

Treatments used in clinical trials haven't yet been shown to be effective. They may have serious or unexpected side effects, and there's no guarantee you'll benefit from them. On the other hand, cancer clinical trials are closely monitored by the federal government to ensure they're conducted as safely as possible. And they offer access to treatments that wouldn't otherwise be available to you.

If you're interested in finding out more about clinical trials, talk to your treatment team. You can also call the National Cancer Institute's Cancer Information Service at (800) 4-CANCER, or (800) 422-6237. The call is free and trained specialists are available to answer your questions. Or visit the National Cancer Institute Web site.




Although it's usually not possible to prevent gallbladder and bile duct cancers, you can take steps to reduce your risk. In general, eating a healthy diet and exercising regularly can lower your risk of many types of cancer.

The American Cancer Society recommends at least five servings of fruits and vegetables every day, along with six servings of foods from other plant sources such as whole-grain breads, cereals, rice and beans. In addition, try to limit fats to no more than 30 percent of your total calories.

Other steps you can take to reduce your risk of gallbladder cancer include the following:

Protecting yourself against bile duct cancer
Avoid toxic chemicals. Among these are highly hazardous substances such as dioxin — a byproduct of plastics and chlorinated pesticide manufacturing — and PCBs, which were used in a number of industrial materials manufactured before 1980. Because PCBs don't break down easily, they're still found worldwide in the air, water, soil and especially in fish. Also implicated in bile duct cancers are nitrosamines, a group of carcinogenic chemicals found in products ranging from tobacco leaves to cured meats.


Coping skills


Learning you have any life-threatening illness can be devastating. But coping with a diagnosis of biliary tract cancer can be especially difficult. The more advanced the disease when it's discovered, the less likely the chance of real recovery. As a result you may feel especially overwhelmed just when you need to make crucial decisions. Although there are no easy answers for people dealing with biliary tract cancer, some of the following suggestions may help:


Complementary and alternative medicine


More and more people are interested in nontraditional approaches to healing, especially when standard treatments produce intolerable side effects or aren't able to provide a cure. To address this growing interest, the National Institutes of Health established the National Center for Complementary and Alternative Medicine (NCCAM) in 1992. The center's mission is to explore nontraditional therapies in a scientifically rigorous way. In 1999 NCCAM teamed up with the National Cancer Institute specifically to look at the role complementary and alternative medicine may play in the treatment of cancer. In general, alternative medicine refers to therapies such as mistletoe or coenzyme Q-10 that may be used instead of conventional treatments. Complementary or integrative medicine, on the other hand, usually means therapies used in conjunction with traditional treatments.

Rather than simply addressing a problem with the body, complementary and alternative treatments often focus on the entire person — body, mind and spirit. As a result, they can be especially effective at reducing stress, alleviating the side effects of conventional treatments such as chemotherapy and improving quality of life.


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