Clinical Training:  Toxic Liver and Failure

Drs. Willis C. Massrey and David R. Nelson

Cite the risk factors for drug-induced hepatotoxicity; Review the mechanisms of hepatotoxicity due to acetaminophen, isoniazid, troglitazone, phenytoin, amiodarone, minocycline; and amoxicillin and potassium clavulanate; Discuss liver failure resulting from hepatitis C infection; Interpret the model for end-stage liver disease (MELD) system and Child-Pugh classification scores to monitor and predict mortality from liver disease; and Recognize spontaneous bacterial peritonitis and refractory ascites.